In the Strodel group we work on the development of biomolecular simulation methods and their application to various problems from the fields of biophysics and biochemistry. In particular, we focus on following topics: protein aggregation in Alzheimer's disease, amyloid-lipid interactions, protein-protein docking, computational enzyme design, and the calculation of experimental observables from biomolecular simulations. For more information, visit our Research website.
Epigallocatechin-3-gallate preferentially induces aggregation of amyloidogenic immunoglobulin light chains
M. Hora, M. Carballo Pacheco, B. Weber, V. K. Morris, A. Wittkopf, J. Buchner, B. Strodel & B. Reif
Sci. Rep., DOI: 10.1038/srep41515 (2017)
Conformational Transitions of the Amyloid-β Peptide Upon Copper(II) Binding and pH Changes.
Q. Liao, M. C. Owen, O. O. Olubiyi, B. Barz, & B. Strodel
Israel J. Chem., DOI: 10.1002/ijch.201600108 (2017)
A combination of mutational and computational scanning guides the design of an artificial ligand-binding controlled lipase
M. Kaschner, O. Schillinger et al.
Sci. Rep., DOI: 10.1038/srep42592 (2017)